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KMID : 0368019830060020145
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Journal of Soonchunhyang University
1983 Volume.6 No. 2 p.145 ~ p.149
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Effect of Cingulate Cortical Ablation on Irritability and Aggressive Behavior of Male Rats
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Abstract
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The study was planned to evaluate the effects of removal of the cingulate cortex upon_ the occurrence of aggressive behaviors and irritabilities, and to compare the effects of cingulectomy with those of operated control and normal control animals.
Sixty male albino rats (Sprague-Dawley strain) were divided into 3 groups: The cingulate group in which the subcallosal portion of the cingulate cortex was ablated through a. slit shaped opening (1mm in width, 5mm in length) on each side of the sagittal suture in the frontal bone (N=21), the operated control group which received only scalp incision(N =19), and normal control group (N=20).
Twenty observation cages (each of which housed a subject and was provided with food and water ad libitum) were arranged in 1 row on a rack. All testing was performed during the dark phase of a reversed light/dark cycle.
Irritability was rated using a 5-category scale: (1) biting reaction to a pencil presented_ 1-2cm. in front of the rat´s snout, (2) biting reaction to a gloved hand presented into the open cage 1-2cm. in front of the rat´s snout, (3) resistance to holding by the gloved. hand, (4) resistance to capture, and (5) vocalization during testing. To determine aggressiveness (mouse killing), an albino mouse weighing approximately 20 gm. was placed in each rat´s cage for 20 min., and instances of killing were recored.
Results obtained were as follows:
There were no significant differences found in the cingulate group, compared with those of operated control and normal control group.
Based on the above mentioned results, it was inferred that the cingulate cortex tended to exert no influence upon the irritability and the aggressive behavior of male rats.
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